G. Zhang, S. Bearden
Clemson University, Clemson, SC, USA
It is necessary to understand and control nanopore behavior in order to develop biosensors for a variety of applications including DNA sequencing. The fluidics of nanopore devices we fabricated exhibits a range of interesting phenomena, such as enhanced conductance and current rectification. By electrically biasing nanopores, we were able to actively control the nanopore conductance in real time ...
Analysis of Heat Transfer in a Complex Three Dimensional Structure Fabricated by Additive Manufacturing - new
C. Settle, K. Hoshino
Biomedical Engineering Department, University of Connecticut, Storrs, CT, USA
The goal of this study was to create a three dimensionally designed biomedical device with multiple functionalities and analyze its simulated heat transfer. The device would be fabricated through additive manufacturing; specifically electron beam melting (EBM). EBM has a feature size constraint of 1 mm (acceptable for this design) and is only capable of manufacturing titanium alloys ; a ...
A.K. Dwivedi, R.M. Patrikar, R.B. Deshmukh, and G. Pendharkar
Visvesvaraya National Institute of Technology, Nagpur, Maharashtra, India
Testing and verification is very important to increase reliability of a system. In water analysis its purity is verified using different test methods. Biosensors are very useful to detect the microorganisms present in water. This paper presents a method to detect E.coli bacteria in water depending upon the capacitance modulation in the presence and absence of E.coli cell, which is simulated in ...
Numerical Prediction of Particle Dynamics Within a Cytometer. Application to Counting and Sizing by Impendance Measurement
HORIBA Medical, Montpellier, France
This paper describes how to numerically tackle the problem of counting and sizing particles by impedance measurement in an orifice–electrode system. The model simulate the particle dynamics submitted to strong hydrodynamic stresses through a microorifice and compute the voltage pulses generated by the modification of the inner dielectric medium. This FSI problem is solved on a moving mesh by ...
Y. Huang, and A. Mason
Electrical and Computer Engineering, Michigan State University, East Lansing, Michigan, USA
This paper describes the modeling of an electrochemical biosensor embedded in a microfluidic channel to determine the concentration of a target biomolecule. The total amount of analyte in the sample can be calculated by integrating the analyte concentration over the duration of the peak current. The biosensor is constructed by immobilizing redox-enzyme on an interdigitated array (IDA) electrode ...
A. Chanda, A.R. Choudhury, G. Ray, K. Dasgupta, and D. Nag
Jadavpur University, Kolkata, West Bengal, India
Atherosclerosis in arteries is caused by the formation of stenosis : fatty depositions, on the artery wall. In current medicine, the practice is to observe the maximum percentage occlusion at any arbitrary cross-section and diagnose the patient on that basis, which might not always present the real picture due to non-uniformity of the stenosis thickness. The present work attempts to simulate the ...
Institute for information and communication technologies, Bulgarian Academy of Sciences, Sofia, Bulgaria
Various haematological diseases, including leukaemia, are characterized by abnormal production of particular blood cells. Two important properties of haematopoietic stem cells (HSCs) are used in their therapy, namely: a) rapid migratory activity and ability to \'\'home\'\' to their niche in the bone marrow; b) high self-renewal and differentiation capacity, responsible for the production and ...
A. Jeremic, E. Khosrowshahli
McMaster University, Hamilton, ON, Canada
Although mammography is extremely important diagnostic technique, it suffers from some limitations such as false negative and positive results, using ionizing radiation and patient’s discomfort. Microwave imaging has been recently proposed as an additional medical imaging technique which can potentially overcome some of the shortcomings of the mammography. We believe that the accuracy of ...
M. Miliani, F. Piccagli, C. Silvestro
Medtronic Invatec S.p.A., Roncadelle, Italy
Introduction: Chronic arterial hypertension (HTN) is a pathological condition characterized by prolonged high level of arterial blood pressure causing major damages to several human body apparata. Renal sympathetic denervation (RDN) has been found to effectively reduce systemic blood pressure. Metallic electrodes can be placed on an endovascular device connected to external radio frequency (RF) ...
BD Medical - Medical Surgical Systems, Helsingborg, Sweden
Anders B Nilsson graduated M. Sc. in engineering physics from Lund University in Sweden. He has been working in the R&D department at BD Medical as principal engineer and project leader since 2005. He uses COMSOL for a wide range of functions, such as early concept development and qualification of products.