Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

A Mathematical Tool for Studying Drug Delivery to the Eye in Case of Glaucoma

P. Silva[1], J.A. Ferreira[2], P. de Oliveira[2]
[1]Coimbra Institute of Engineering, CMUC, Coimbra, Portugal
[2]Department of Mathematics University of Coimbra, CMUC, Coimbra, Portugal

The aim of the poster is to present a coupled 2D mathematical model to predict the evolution of drug concentration - in the cornea and in the anterior chamber of the eye - when therapeutic lenses are used (Figure 1). The mathematical model takes into account (i) diffusion processes in several compartments of the eye (therapeutic lens, cornea and anterior chamber); (ii) metabolic consuming ...

Can Oscillatory Convection Accelerate Signal Propagation in Simple Epithelium?

M. Nebyla[1], M. Pribyl[1]
[1]Institute of Chemical Technology, Prague, Department of Chemical Engineering, Prague, Czech Republic

We introduce a mathematical model of signal transmission in simple epithelial layers. The mathematical model consists of reaction-transport equations for extracellular ligands, cellular receptors, ligand-receptor complexes and a ligand releasing protease. We consider diffusion and nonstationary convective transport of protein ligands in the extracellular space. The study was carried out using ...

Modelling the Response of Microdialysis Probes in Glucose Concentration Measurement

J.M. Gozálvez-Zafrilla[1], A. Santafé-Moros[1], J.L. Díez-Ruano[2], J. Bondia[2]
[1]Institute for Industrial, Radiophysical and Environmental Safety (ISIRYM) - Universitat Politècnica de Valencia, Valencia, Spain
[2]Instituto Universitario de Automática e Informática Industrial (AI2) - Universitat Politècnica de Valencia, Valencia, Spain

Microdialysis is a technique of continuous glucose monitoring in diabetic patients. In microdialysis, a saline serum is perfused into a microdialysis probe. Glucose pass from the plasmatic fluid through the porous membrane. The glucose concentration in the dialysate obtained is measured by an external analytical device. This preliminary work aimed to obtain a model to relate glucose ...

Microwave Exposure System for In Vitro and In Vivo Studies - new

C. Nadovich[1, 2], W. D. Jemison[2], J. A. Stoute[3], C. Spadafora[4]
[1]Lafayette College, Easton, PA, USA
[2]Clarkson University, Potsdam, NY, USA
[3]Pennsylvania State University, Hershey, PA, USA
[4]INDICASAT AIP, Ciudad del Saber, Panama

A computer controlled microwave exposure system and specialized applicators were constructed for the purpose of facilitating accurate observations of microwave radiation effects on uninfected and infected biological tissue in vitro and in vivo under different electromagnetic modalities and exposure configuration. To address diverse requirements, three different applicators were developed: a ...

Designing Polymer Thick Film Intracranial Electrodes for use in Intra-Operative MRI Setting.

G. Bonmassar[1], and A. Golby[2]
[1]AA. Martinos Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
[2]Department of Neurosurgery, Brigham and Women’s Hospital, Boston, Massachusetts, USA

A new type of MRI compatible intracranial electrode based on Polymer Thick Film (PTF) is presented and studied using COMSOL Multiphysics. The geometry considered was a two-dimensional cross section cut of 5 mm thick electrodes with 5 cm leads on top of a 2×10 cm slab representing Gelfilm, or the substrate. The resistive leads were compared with metallic leads to estimate the ...

Modeling of snRNP Motion in the Nucleoplasm

M. Blaziková[1], J. Malínský[2], D. Stanek[3], and P. Herman[1]
[1]Faculty of Mathematics and Physics, Charles University, Prague, Czech Republic
[2]Institute of Experimental Medicine, Prague, Czech Republic
[3]Institute of Molecular Genetics, Prague, Czech Republic

Small nuclear ribonucleoprotein particles (snRNPs) are essential supramolecular complexes involved in pre-mRNA splicing, the process of post-transcriptional RNA modifications. The particles undergo complex assembly steps inside the cell nucleus in a highly dynamic compartment called the Cajal body. We have previously shown that the free diffusion model does not fully describe the snRNP motion ...

Analyzing Drug Delivery and Osteoblast Growth on a Porous Scaffold in a Perfusion Bioreactor

A. Sun, and S. Murray
Dept. of Biomedical Engineering
UCLA, Los Angeles, CA

Implantable Collagen sponges are used in Spinal Surgery as Drug Delivery Scaffolds. An optimal concentration of growth factor that strikes a balance between bone growth and adverse diffusion effects is difficult to find. The porous sponge also serves as a scaffold for Osteoblast growth, and fluid shear has been shown to mediate biological effects on that cell type. We use COMSOL Multiphysics ...

Electrical Response and Thermal Damage Assessment of Cutaneous and Subcutaneous Tissues to Noninvasive Radiofrequency Heating: A Computational Modeling Study

A. González-Suárez[1,2], J. N. Jimenez-Lozano[3], W. Franco[1]
[1]Wellman Center for Photomedicine, Massachusetts General Hospital & Harvard Medical School, Boston, MA, USA
[2]Biomedical Synergy, Electronic Engineering Department, Universitat Politècnica de València, Valencia, Spain
[3]ZELTIQ Aesthetics, Inc., Pleasanton, CA, USA

Electromagnetic radiofrequency (RF) sources are widely used to heat up cutaneous and subcutaneous tissues. The subcutaneous morphology of tissue consists of a fine, collagenous and fibrous septa network enveloping clusters of adipocyte cells; however, it is commonly regarded as a homogeneous fat layer in computational models. In the present study the objective is to assess the effect of the ...

Simulation of Convection in Water Phantom Induced by Periodic Radiation Heating

H.H. Chen-Mayer[1], and R. Tosh[1]
[1]Ionizing Radiation Division, National Institute of Standards and Technology, Gaithersburg, Maryland, USA

Water calorimetry is employed to establish a primary reference standard for radiation dosimetry by measuring the temperature rises in a water phantom (a cube of about 30 cm x 30 cm x 30 cm) subjected to a beam of ionizing radiation.  We use COMSOL Multiphysics to model the system using the Heat Transfer module and the Incompressible Navier-Stokes module with a geometry of 2D-axial ...

Finite Element Modeling a Redox-Enzyme-Based Electrochemical Biosensor

Y. Huang[1], and A. Mason[1]
[1]Electrical and Computer Engineering, Michigan State University, East Lansing, Michigan, USA

This paper describes the modeling of an electrochemical biosensor embedded in a microfluidic channel to determine the concentration of a target biomolecule. The total amount of analyte in the sample can be calculated by integrating the analyte concentration over the duration of the peak current. The biosensor is constructed by immobilizing redox-enzyme on an interdigitated array (IDA) electrode ...