Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

Deformable Image Registration for Pleural Photodynamic Therapy

B. Liu[1], T. C. Zhu[1]
[1]Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

Deformable image registration is a form of medical image processing that can provide insights into the development of phenomenon and variation in normal anatomical structure over time. Prior to post-operative pleural photodynamic therapy (PDT), a series of CT scans of lungs will be acquired. During PDT treatment, an infrared navigation system is used to contour the lungs and provide real-time ...

Elucidating the Mechanism Governing the Cell Rotation Behavior Under DEP

G. Zhang[1], Y. Zhao[1], J. Brcka[2], J. Faguet[2], E. Lee[2]
[1]Clemson University, Clemson, SC, USA
[2]TEL U.S. Holdings, Inc., U.S. Technology Development Center, Austin, TX, USA

In our experiments with manipulating cells with DEP, we noted that some cells are constantly spining. By hypothesing that the cell spining is caused by the non-circular shape of the cell body and the off-centered location of its nucleus and that the rotation direction depends on the relative location of nucleus with respect to the electrical field, we found that the observed cell rotation was ...

Simulation and Experimental Analysis of Drug Release Rates from Magnetic Nanocomposite Spheres - new

L. Saeeednia[1], H. Mehraein[2], F. Abedin[1], K. Cluff[2], R. Asmatulu[1]
[1]Department of Mechanical Engineering, Wichita State University, Wichita, KS, USA
[2]Department of Bioengineering, Wichita State University, Wichita, KS, USA

Targeted drug delivery systems have been wildly studied in cancer therapy due to the toxicity of most of chemotherapeutic drugs. Nanoparticles can be attached to the small molecules of the drugs and serve as drug carriers to deliver the drug molecules into the area of interest. In this research, polymeric microspheres containing biodegradable poly(D, L-lactide-co-glycolide) (PLGA), magnetic ...

基于 DTI 纤维追踪和有限元力学模型的脑损伤轴突纤维损伤研究

李娜 [1], 李江红 [2]
[1] 中南大学湘雅三医院,长沙,湖南,中国
[2] 中车集团南车研究所,株洲,湖南,中国

研究头部损伤机理是对运动撞击中脑损伤进行预测的有效手段。数学模型是分析损伤实验数据、预测人员碰撞损伤程度的唯一方法,但现有的头部损伤有限元模型基于尸体实验数据,且忽略脑组织结构的各向异性。本项目旨在提出并实现一种以损伤生物力学为基础、结合磁共振扫描 DTI 的轴突走向信息的有限元力学模型。提取脑外伤前的弥散张量成像信息,实现深入到轴突水平有限元力学模型的建立,在有限元模拟中采用非线性超弹性力学模型,并植入 NSGAII 最优化方法对有限元模型的材料参数进行优化,从而提高模型的稳定性和计算精度;将计算预测结果与损伤后 DTI 的 FA 值所表现的轴突断裂情况进行验证, 探索活体环境下碰撞损伤中脑轴突的损伤性变化,从而获得脑外伤损伤程度与力学因素之间的关系,为脑外伤损伤程度的预测和脑外伤损伤标准的校正提供精确完整的信息。本项目的研究成果将在汽车碰撞的乘员防护设计上有重要的理论指导价值。 ...

Simulations of Microelectrode and Neuron Interfaces Enable Long-Term and High Fidelity Recordings

P. Wijdenes [1], H. Ali [2], N. Syed [3], C. Dalton [2],
[1] Centre for Bioengineering Research and Education, University of Calgary, Calgary, AB, Canada
[2] Department of Electrical and Computer Engineering, Schulich School of Engineering, University of Calgary, Calgary, AB, Canada
[3] Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada

Our inability to record single cell activity with high resolution over a long period of time precludes fundamental understanding of nervous system functions, both under normal and pathological conditions. While the fabrication of current micro- and nano-electrodes has advanced our capabilities to perform long-term recordings, this has been at the expense of signal resolution due to low sealing ...

Frequency and Electrode Separation Recommendations for EDA Measurements

S. Sridhar [1], T. J. Akl [1],
[1] Analog Devices Inc., Wilmington, MA, USA

Electrodermal Activity (EDA) is a measure of changes in the conductivity of the skin. It has have been found to be indicative of the individual’s autonomic nervous activity which is correlated to their stress and emotional state. These conductivity changes are tracked by injecting a small electric current directly into the skin and measuring the induced voltage drop over time. With increase in ...

Computational Modeling to Study the Treatment of Cardiac Arrhythmias using Radiofrequency Ablation

A. González-Suárez[1], M. Trujillo[2], J. Koruth[3], A. D'Avila[3], E. Berjano[1]
[1]Biomedical Synergy, Electronic Engineering Department,Universitat Politècnica de Valencia, Valencia, Spain
[2]Instituto Universitario de Matemática Pura y Aplicada, Universitat Politècnica de Valencia, Valencia, Spain
[3]Helmsley Cardiac Electrophysiology Center, Mt SinaiMedicalCenter and School of Medicine, New York, NY, USA

Previous studies proposed using bipolar radiofrequency ablation across two catheters placed on opposing surfaces of the ventricular wall to create transmural lesions. 2D and 3D models were built and solved with COMSOL Multiphysics software. With these models, it was possible to study the temperature distribution and lesion geometry (Figure), to compare the potential of two ways of applying ...

Laser Interstitial Thermo Therapy (LITT) for Prostate Cancer Animal Model: Numerical Simulation of Temperature and Damage Distribution

M.F. Marqa, P. Colin, P. Nevoux, S. Mordon, and N. Betrouni
University of Lille, CHRU, Lille, France

Laser interstitial thermotherapy (LITT) is a cancer treatment technique in which laser fibers are introduced inside the tumor. While it destroys deep tumors, the LITT procedure allows minimizing the impact on adjacent healthy structures. One of the effective methods to perform treatment planning for LITT is simulation. We used COMSOL Multiphysics to simulate the heat distribution and thermal ...

The Effect of Cartilaginous Rings on Deposition by Convection, Brownian Diffusion and Electrostatics

H. Akerstedt
Luleå University of Technology, Luleå, Sweden

This paper presents a numerical study of the deposition of spherical charged nanoparticles caused by convection and Brownian diffusion in a pipe with a cartilaginous ring structure. The model is supposed to describe deposition of charged particles in the upper generations of the tracheobronchial tree of the human lung. The upper airways are characterized by a certain wall structure called ...

Understanding the Role of Nanomaterials in DNA Biosensors Through Finite Element Analysis

J. C. Kumaradas[1], A. Zhang[2], Y. D. Davletshin[1]
[1]Ryerson University, Toronto, ON, Canada
[2]University of Waterloo, Waterloo, ON, Canada

Tremendous progress is being made in the integration of nanoparticles into micro-analytical systems for biosensing. These materials are shown to enhance the analyte capture capability of biosensing platforms. We have implemented a computational model that considers the sensor’s geometry, size, analyte concentration and type to predict the number of nucleic acid molecules captured by ...