M. Nickaeen , I. L. Novak , A. Mogilner , B. M. Slepchenko ,
 Richard D. Berlin Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, CT, USA
 Courant Institute and Department of Biology, New York University, New York, NY, USA
A recently published conservative algorithm for simulating reactions and transport in moving domains have been extended to models in which cell kinematics are coupled with intracellular dynamics. For this, the method that combines a Eulerian approach with tracking an explicit boundary was linked to FronTier, a robust front-tracking technique. The extended algorithm was validated using a set of ...
K. Carlson , J. Arle , J. L. Shils , L. Mei ,
 Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, USA
 Rush Medical Center, Chicago, IL, USA
In 1901 Weiss proposed an equation predicting activation of nerve fibers by electrical stimulation, used in neuroscience and neuromodulation, which applies electric fields to modify nerve behavior in neurological disorders. Weiss’ equation is relative to geometry, electrode array, tissue conductivities, and waveform since it uses electrode amplitude. We replicated a leading calibrated nerve ...
吴淑莲 , 李晖 , 李志芳 ,
引言：激光诱导间质肿瘤热疗法是一种可使生物组织局部地方凝结坏死的肿瘤疾病治疗方法，目前已经用于肝、脑等各部位的肿瘤治疗[1-2]。为了更好地进行肿瘤疾病的治疗，需要实时地对组织的温度和热损伤进行监控，而检测技术很难实现对肿瘤治疗过程的实时监测，故数值计算成为研究光热疗法的有力工具[2-6]。本模型将生物组织光传输的物理场与热传输的物理场相耦合，考虑组织光热参数随温度变化的情况，研究了肿瘤周围含有大动脉的情况时组织的温度分布随时间的变化情况，研究结果对指导临床医学肿瘤治疗有重要意义。 COMSOL Multiphysics® 的软件使用： 几何模型：如图1所示，圆柱代表光源，圆形区域代表肝脏肿瘤，弯曲圆柱代表大血管，大正方体代表肝脏。 PDE 接口和生物传热接口，选择生物组织的热损伤。 结果： 如图2，图3所示，在加热过程中，开始时血管对温度分布几乎无影响，但是随着加热时间变长 ...
D. W. Pepper , S. Pirbastami ,
 University of Nevada - Las Vegas, Las Vegas, NV, USA
Bioresorbable stents are providing temporary mechanical support to keep a narrowed or blocked coronary artery open and restore the blood flow and will be gradually degraded and resorbed after the healing and remodeling of arterial wall. This new generation of stents has lower rates of restenosis and in-stent thrombosis in comparison with permanently bare-metal stents. Since this new generation ...
Simulation of a Magnetic Induction Method for Determining Passive Electrical Property Changes of Human Trunk Due to Vital Activities
H. Mahdavi, J. Rosell Ferrer
Universitat Politècnica de Catalunya, Barcelona, Spain
The human body consists of many different types of tissues each with specific passive electrical properties. Vital activities lead to a characteristic change of these properties and geometrical changes. Magnetic induction is a non-contact method which can be used to determine these changes. The method is based on the creation of a primary magnetic field that will produce eddy currents in the ...
Influence of Non-Newtonian Blood Viscosity on Wall Pressure in Right Coronary Arteries with Serial Stenoses
B. Liu 
 Monmouth University, West Long Branch, NJ, USA
Three dimensional mathematical models are developed to simulate the blood flows in patient specific right coronary arteries with two stenoses. Simulations are carried out with various flow parameters under physiological conditions. Both Newtonian and non-Newtonian blood viscosity models are applied in the simulations to examine the influence of non-Newtonian viscosity of blood on the wall ...
Investigating the Loading Behaviour of Intact and Meniscectomy Knee Joints and the Impact on Surgical Decisions
M. S. Yeoman ,
 Continuum Blue Ltd., Cardiff, United Kingdom
Knee joints are often subject to high loads, which can lead to injury, malalignment, and the progression of osteoarthritis in patients. To better understand the behavior, and the effect of meniscal damage and different meniscectomy repair approaches, a 3D structural mechanics model of a patient specific knee was developed in COMSOL Multiphysics®. The model made use of the Structural Mechanics ...
Multiphysics Modeling of Cellular Arrays Using Periodic Minimal Surfaces – A Drug and Gene Delivery Application
J.I. Rey, A.J. Llewellyn, R.J. Connolly, J.P. Jimenez, A.M. Hoff, and R.A. Gilbert
University of South Florida, Tampa, FL, USA
Minimal surfaces are found in nature from crystalline structures to biological nano and micro structures such as biomembranes, and osseous formations in sea urchin. An application to electrically mediated drug and gene delivery is presented. Periodic level surfaces which approximate minimal surfaces are used to generate a geometric representation of tissue. A method to create such structures ...
E. Engström, B. Balfors, and R. Thunvik
Royal Institute of Technology, Stockholm, Sweden
In this study we evaluate transport, retention and subsistence of Escherichia coli (E. coli), a common fecal indicator bacteria, in a model (2x1m) of a constructed wetland. Transport occurs in the unsaturated and saturated zone. Inactivation is accounted for as a kinetic first-order process. Retention is assumed to be dominated by solid-air-water interface straining and is modeled with a kinetic ...
Investigation of the Effect of Spinal Defects on Spondylolysis and Stress Fracture of Vertebral Bodies
M.S. Yeoman, C. Quah, A. Cizinauskas, K. Cooper, D. McNally, B. Boszczyk
Continuum Blue, Tredomen, Ystrad Mynach, United Kingdom
The Centre for Spinal Studies and Surgery, Queen’s Medical Centre, Nottingham, United Kingdom
Bioengineering Research Group, Faculty of Engineering, The University of Nottingham, Nottingham, United Kingdom
Spondylolysis (SL) is a defect of the spinal vertebra, and is typically caused by stress fracture of the pars interarticularis bone of the vertebral arch. It is especially common in adolescents who over train in sporting activities. Spina bifida occulta (SBO) is a malformation of the spine where the protruding vertebral bodies are not fully formed. In this study we demonstrate the predisposition ...