T. C. Zhu, B. Liu
University of Pennsylvania, Philadelphia, PA, USA
Singlet oxygen (1O2) is the major cytotoxic agent that kills cells during photodynamic therapy (PDT). Based on a previously-developed model, the distance-dependent reacted 1O2 can be numerically calculated using finite-element method. We improved the model to include microscopic kinetic equations of oxygen diffusion from uniformly distributed blood vessels to the adjacent tissue. The blood ...
A Multiphase Porous Medium Transport Model with Distributed Sublimation Front to Simulate Vacuum Freeze Drying
A. Warning, J. M. R. Arquiza, A. K. Datta
Cornell University, Ithaca, NY, USA
A continuum, porous medium formulation with non-equilibrium sublimation was developed and validated for freeze drying without and with uniform microwave volumetric heating. The model incorporates the effect of Knudsen flow at low pressure and low permeability freeze drying. The distributed, non-equilibrium sublimation demonstrated that the sublimation front is a sharp boundary for high ice ...
R. Santoprete, B. Querleux
L'Oréal, Paris, France
To better quantify the impact of the morphological and mechanical properties of the main constituents of the stratum corneum (SC, the outermost layer of the skin) on its overall mechanical behavior, we developed a biomechanical model of the SC at a cellular scale, based on in vitro morphological and mechanical data. The sensitivity analysis quantified the relative impact of the mechanical and ...
M. Miliani, F. Piccagli
Medtronic Invatec S.p.A., Roncadelle, BS, Italy
During peripheral intravascular interventions one of the main issues is the correct deployment of the guidewire (GW) to the anatomical site which has to be treated, often supported by a microcatheter. There is a trade-off between the microcatheter flexibility and its push-ability to be able to reach the anatomical site. The catheter design has been defined with 2 transition zones. A parametric ...
S. Nikolaev, A. Trubuil
Institute of cytology and genetics SB RAS, Novosibirsk, Russia
Institut National de la Recherche Agronomique, Jouy-en-Josas, France
We used a predefined COMSOL Multiphysics® interface to imitate biological growth and shape change (morphodynamics). We found a set of parameters that supply observed morphodynamics for an Arabidopsis embryo during its transition from globular to heart stage.
K. Basu, P. Ghosh, S. Bhattacharjee, S. Das , A. Chanda
School of Bio Science and Engineering, Jadavpur University, Kolkata, West Bengal, India
Department of Mechanical Engineering, Jadavpur University, Kolkata, West Bengal, India
Cardiovascular disease has become a major healthcare problem. To tackle this along with bypass surgery, the use of the cardiovascular stent is considered promising and effective. In this study, we aim to find the effectiveness of stent deployments and their influence on haemodynamics post their deployment in human arteries. For the study we have reconstructed single units of two commercially ...
Biofluid-Structural Interaction in Abdominal Aortic Aneurysm for Predicting Timeline to Rupture: The Effect of Hypertension and Aorta Wall Material Properties - new
K. Cluff, H. Mehraein, G. Jayakumar
Bioengineering, Wichita State University, Wichita, KS, USA
Industrial & Manufacturing Engineering, Wichita State University, Wichita, KS, USA
An abdominal aortic aneurysm (AAA) is a bulge formed in the large blood vessels that supply blood to the abdomen, pelvis, and legs. A fluid structure interaction model was developed in a 3D aortic aneurysm model, which was constructed from abdominal CT scan images. Combining medical imaging and computational fluid dynamics (CFD) in a time dependent study allowed the determination of wall ...
A. Warning, A. K. Datta
Department of Biological & Environmental Engineering, Cornell University, Ithaca, NY, USA
Hydrocooling is the process by which warm produce is chilled with water. The chilling of warm produce generates a negative pressure differential between the produce (warm) and (cold) water due to the condensation of water vapor inside the produce which forms a vacuum and can pull in contaminated water through an opening. A porous media based model of water infiltration was developed using a ...
S. D. Evans, J. S. Roth, M. R. Cheetham
University of Leeds, Leeds, UK
Brownian ratchets and electric fields are used for the transport of membrane components. Transport is achieved through the combination of a pattern with free diffusion. We show a good agreement between simulation and experiment, therefore allowing for further optimisation of the ratchets using COMSOL Multiphysics. In addition to the transport device we also introduce the possibility to ...
G. E. Svedberg, L. Lama, J. Gantelius
Science for Life Laboratory, Stockholm, Sweden
Paper based lateral flow assays are widely used as point of care devices for disease diagnostics due to their low cost, short run time and ease of use. Binder molecules specific for certain molecular biomarkers of interest are typically deposited as dots or lines on paper strips, whereupon sample can be flowed through the paper strip via capillary forces in order to measure the concentration of ...