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Model ID: 1391

Degradation of DNA in Plasma

Biotechnology is a rapidly growing area in the pharmaceutical sciences. One example of a clinical application is gene therapy, where it is possible to produce proteins in vivo, using the body’s own mechanisms for protein production. Major issues in gene delivery involve the transport of plasmid DNA (pDNA) to target sites and the conversion between different forms of pDNA.

This model illustrates the use of the Parameter Estimation feature of the Reaction Engineering interface to find the rate constants of the three consecutive reactions involved in a DNA degradation process.

A global plot resulting from reading in experimental data and comparing it to simulation results.

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